Mgbochi mmadụ TIMP1 Antibody, Mouse Monoclonal
Nkọwa ngwaahịa
Ozi izugbe
TIMP metallopeptidase inhibitor 1, nke a makwaara dị ka TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-ike ọrụ, TPA-S1TPA-induced proteinTissue inhibitor nke metalloproteinases 1, bụ a eke inhibitors nke matrix metalloproteinases otu (people inhibitors). na-etinye aka na mmebi nke matrix extracellular.A na-ahụ TIMP-1/TIMP1 na anụ ahụ nwa ebu n'afọ na ndị okenye.A na-ahụ ọkwa kachasị elu na ọkpụkpụ, ngụgụ, ovary na akpanwa.Mgbagwoju anya nwere metalloproteinases ma na-emezigharị ha site na ijikọ na zinc cofactor nke catalytic ha.TIMP-1/TIMP1 na-ebute erythropoiesis in vitro;ma, n'adịghị ka IL-3, ọ bụ ụdị-kpọmkwem, na-akpali uto na iche nke naanị mmadụ na murine erythroid progenitors.Na mgbakwunye na ọrụ mgbochi ya megide ọtụtụ n'ime MMP ndị a ma ama, protein ahụ nwere ike ịkwalite mmụba cell n'ọtụtụ ụdị sel, ma nwee ike ịnwe ọrụ mgbochi apoptotic.Ntugharị mkpụrụ ndụ ihe nketa protein a bụ ihe a na-agaghị emeli nke ukwuu na nzaghachi nye ọtụtụ cytokines na homonụ.Na mgbakwunye, okwu sitere na ụfọdụ ma ọ bụghị ihe niile X chromosomes na-adịghị arụ ọrụ na-egosi na arụghị ọrụ nke mkpụrụ ndụ ihe nketa a bụ polymorphic na ụmụ nwanyị mmadụ.Mkpụrụ ndụ ihe nketa a dị n'ime intron 6 nke mkpụrụ ndụ synapsin I ma degharịa ya n'akụkụ nke ọzọ.Mgbagwoju anya nwere metalloproteinases ma na-emezigharị ha site na ijikọ na zinc cofactor nke catalytic ha.A maara TIMP-1/TIMP1 ime ihe na MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 na MMP-16.
Njirimara
| Nkwanye ụzọ abụọ | CLIA (Nchọpụta-Nchọpụta): 1D5-5 ~ 3G11-6 1D12-2 ~ 1G3-7 |
| Ịdị ọcha | > 95% dị ka SDS-PAGE siri kpebie. |
| Nhazi ihe nchekwa | PBS, pH7.4. |
| Nchekwa | Chekwaa ya n'okpuru ọnọdụ adịghị mma na -20 ℃ ruo -80 ℃ mgbe ị na-enweta ya. Na-akwado iwebata protein n'ime obere nha maka nchekwa kacha mma. |
Ntụnyere asọmpi
Ozi ịtụ
| Aha ngwaahịa | Nwamba.Mba | NJ mmepụta oyiri |
| TIMP1 | AB0034-1 | 1D5-5 |
| AB0034-2 | 1D12-2 | |
| AB0034-3 | 1G3-7 | |
| AB0034-4 | 3G11-6 |
Mara: Bioantibody nwere ike ahaziri nha maka mkpa gị.
Nkọwapụta
1.Barylski M, Kowalczyk E, Szadkowska I, et al.[Onye na-egbochi anụ ahụ nke metalloproteinases[J].Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego, 2011, 30 (178): 246-8.
2.Hayakawa T, Yamashita K, Tanzawa K, et al.Ọrụ na-akwalite uto nke onye na-egbochi anụ ahụ nke metalloproteinases-1 (TIMP-1) maka ọtụtụ mkpụrụ ndụ dị iche iche Ihe nwere ike ime ka uto ọhụrụ dị na serum [J].Akwụkwọ ozi FEBS, 1992, 298.
3.Haider DG , Karin S , Gerhard P , et al.Ọbara retinol na-ekekọta protein 4 na-ebelata ka ọ gafechara n'ihe gbasara oke ibu.[J].Akwụkwọ akụkọ nke Clinical Endocrinology & Metabolism (3): 1168-71.
