Mgbochi mmadụ CHI3L1 Antibody, mmadụ Monoclonal
Nkọwa ngwaahịa
Ozi izugbe
Chitinase-3-dị ka protein 1 (CHI3L1) bụ heparin na-ejikọta glycoprotein zoro ezo nke okwu ya na-ejikọta ya na mbugharị mkpụrụ ndụ akwara dị nro.A na-egosipụta CHI3L1 n'ọkwa dị elu na omenala VSMC nodular postconfluent yana na ọkwa dị ala na omenala na-agbasawanye subconfluent.CHI3L1 bụ anụ ahụ na-egbochi, lectin na-ejikọta chitin na onye so na ezinụlọ glycosyl hydrolase 18. N'adịghị ka ọtụtụ ndị ọzọ monocyto / macrophage markers, okwu ya adịghị na monocytes na ike na-akpali n'oge ikpeazụ nkebi nke mmadụ macrophage iche.A na-ejikọta ọkwa dị elu nke CHI3L1 na ọrịa ndị na-egosipụta mmụba nke anụ ahụ na-ejikọta ọnụ, dị ka rheum atoid, ogbu na nkwonkwo, osteoarthritis, scleroderma, na cirrhosis nke imeju, mana a na-emepụta ya na cartilage sitere na ndị na-enye onyinye ochie ma ọ bụ ndị ọrịa nwere ọrịa ogbu na nkwonkwo.A na-egosipụta CHI3L1 n'ụzọ na-adịghị mma na hippocampus nke ndị nwere schizophrenia ma nwee ike itinye aka na nzaghachi cellular na ihe omume gburugburu ebe obibi dị iche iche nke a na-akọ na-abawanye ohere nke schizophrenia.
Njirimara
| Nkwanye ụzọ abụọ | CLIA (Nchọpụta-Nchọpụta): 2E4-2 ~ 1G11-14 13F3-1 ~ 1G11-14 |
| Ịdị ọcha | > 95%, nke SDS-PAGE kpebiri |
| Nhazi ihe nchekwa | PBS, pH7.4 |
| Nchekwa | Chekwaa ya n'okpuru ọnọdụ adịghị mma na -20 ℃ ruo -80 ℃ mgbe ị na-enweta ya. Maka nchekwa ogologo oge, biko wepụ ma chekwaa ya.Zenarị okirikiri oyi na-agbaze ugboro ugboro. |
Nyocha ntụnyere
| Bioantibody | ụlọ ọgwụ chọpụtara ikpe | Mkpokọta | |
| nti | Ihe ọjọọ | ||
| nti | 46 | 3 | 49 |
| Ihe ọjọọ | 4 | 97 | 101 |
| Mkpokọta | 50 | 100 | 150 |
| ntụle nyocha | uche | nkọwapụta | izi ezi |
| 92% | 97% | 95% | |
Ozi ịtụ
| Aha ngwaahịa | Nwamba.Mba | NJ mmepụta oyiri |
| CHI3L1 | AB0031-1 | 1G11-14 |
| AB0031-2 | 2E4-2 | |
| AB0031-3 | 3A12-1 | |
| AB0031-4 | 13F3-1 |
Mara: Bioantibody nwere ike ahaziri nha maka mkpa gị.
Nkọwapụta
1.Kyrgios I , Galli-Tsinopoulou A , Stylianou C , et al.Ọkwa na-ekesa elu nke serum acute-phase protein YKL-40 (protein chitinase 3-dị ka protein 1) bụ akara nke oke ibu na nguzogide insulin n'ime ụmụaka prepubertal[J].Metabolism- Clinical & Experimental, 2012, 61 (4): 562-568.
2.Yu-Huan M, Li-Ming T, Jian-Ying LI, et al.Nyocha na ntinye nke serum chitinase-3-dị ka protein 1, alfa-fetoprotein na nchọpụta ferritin iji chọpụta ọrịa cancer hepatocellular [J].Ọgwụ mgbochi bara uru, 2018.
