Mgbochi mmadụ PLGF Antibody, Mouse Monoclonal
Nkọwa ngwaahịa
Ozi izugbe
Preeclampsia (PE) bụ nsogbu siri ike nke afọ ime nke ọbara mgbali elu na proteinuria na-egosi mgbe izu 20 nke ime ime gasịrị.Preeclampsia na-apụta na 3-5% nke ime ime ma na-ebute nnukwu ọnwụ nke nne na nwa ebu n'afọ ma ọ bụ nwa ọhụrụ na ọrịa.Ngosipụta ụlọ ọgwụ nwere ike ịdịgasị iche site na ụdị dị nro ruo n'ụdị siri ike;preeclampsia ka bụ otu n'ime ihe na-ebute ọrịa nwa ebu n'afọ na nke nne na-anwụ anwụ.
Preeclampsia na-egosi na ọ bụ n'ihi ntọhapụ nke ihe angiogenic sitere na placenta nke na-ebute nkwụsị nke endothelial.A na-agbanwe ọkwa ọbara nke PlGF (placental growth factor) na sFlt-1 (soluble fms-dị ka tyrosine kinase-1, nke a makwaara dị ka soluble VEGF receptor-1) na ụmụ nwanyị nwere preeclampsia.Ọzọkwa, ikesa ọkwa nke PlGF na sFlt-1 nwere ike ịkpa oke afọ ime nkịtị site na preeclampsia ọbụlagodi tupu mgbaàmà ụlọ ọgwụ emee.N'ime afọ ime nkịtị, ihe na-akpata pro-angiogenic PlGF na-abawanye n'ime ọnwa abụọ mbụ ma na-ebelata ka afọ ime na-aga n'ihu ruo ogologo oge.N'ụzọ dị iche, ọkwa nke ihe mgbochi angiogenic sFlt-1 na-anọgide na-eguzosi ike n'oge mmalite na etiti oge ime ime ma na-abawanye nwayọọ nwayọọ ruo oge.N'ime ụmụ nwanyị ndị na-etolite preeclampsia, a chọpụtala ọkwa sFlt-1 dị elu yana ọkwa PlGF achọpụtala na ọ dị ala karịa n'afọ ime nkịtị.
Njirimara
| Nkwanye ụzọ abụọ | CLIA (Nchọpụta-Nchọpụta): 7G1-2 ~ 5D9-3 5D9-3 ~ 7G1-2 |
| Ịdị ọcha | > 95% dị ka SDS-PAGE siri kpebie. |
| Nhazi ihe nchekwa | PBS, pH7.4. |
| Nchekwa | Chekwaa ya n'okpuru ọnọdụ adịghị mma na -20 ℃ ruo -80 ℃ mgbe ị na-enweta ya. Na-akwado iwebata protein n'ime obere nha maka nchekwa kacha mma. |
Ntụnyere asọmpi
Ozi ịtụ
| Aha ngwaahịa | Nwamba.Mba | NJ mmepụta oyiri |
| PLGF | AB0036-1 | 7G1-2 |
| AB0036-2 | 5D9-3 | |
| AB0036-3 | 5G7-1 |
Mara: Bioantibody nwere ike ahaziri nha maka mkpa gị.
Nkọwapụta
1.Brown MA, Lindheimer MD, de Swiet M, et al.Nkewa na nchoputa nke ọrịa hypertensive nke afọ ime: nkwupụta sitere na International Society for Study of Hypertension in Pregnancy (ISSHP).Ime ime hypertens 2001;20 (1):IX-XIV.
2.Uzan J, Carbonnel M, Piconne O, et al.Pre-eclampsia: pathophysiology, nchoputa, na njikwa.Vasc Health Risk Manag 2011; 7: 467-474.
