Ozi izugbe
IGFBP1, nke a makwaara dị ka IGFBP-1 na insulin-dị ka ibu ihe na-ejikọta protein 1, bụ onye otu ezinụlọ protein na-ejikọta insulin-dị ka uto na-ejikọta.IGF na-ekekọta protein (IGFBPs) bụ protein nke 24 ruo 45 kDa.All isii IGFBPs na-ekere òkè 50% homology na nwere njikọ chiri anya maka IGF-I na IGF-II n'otu usoro nke ịdị ukwuu dị ka ligands nwere maka IGF-IR.Ndị na-edozi ahụ na-ejikọta IGF na-agbatị ọkara ndụ nke IGF ma gosipụta ya ma ọ bụ gbochie ma ọ bụ kpalie mmetụta na-akwalite uto nke IGF na omenala cell.Ha na-agbanwe mmekọrịta nke IGF na ndị na-anabata elu cell ha.IGFBP1 nwere ngalaba IGFBP yana ngalaba thyroglobulin ụdị-I.Ọ na-ejikọta ma insulin-dị ka ihe na-eto eto (IGFs) I na II ma na-ekesa na plasma.Njikọ nke protein a na-agbatị ọkara ndụ nke IGF ma gbanwee mmekọrịta ha na ndị na-anabata elu cell.
Nkwanye ụzọ abụọ | CLIA (Nchọpụta-Nchọpụta): 4H6-2 ~ 4C2-3 4H6-2 ~ 2H11-1 |
Ịdị ọcha | > 95% dị ka SDS-PAGE siri kpebie. |
Nhazi ihe nchekwa | 20mM PB, 150mM NaCl, 0.1% Proclin 300, pH7.4 |
Nchekwa | Chekwaa ya n'okpuru ọnọdụ adịghị mma na -20 ℃ ruo -80 ℃ mgbe ị na-enweta ya. Na-akwado iwebata protein n'ime obere nha maka nchekwa kacha mma. |
Bioantibody | Achọpụtara ụlọ ọgwụ | Mkpokọta | |
Nke dị mma | Ihe ọjọọ | ||
Nke dị mma | 35 | 0 | 35 |
Ihe ọjọọ | 1 | 87 | 88 |
Mkpokọta | 36 | 87 | 123 |
Nkọwapụta | 100% | ||
Mmetụta | 97% |
Aha ngwaahịa | Nwamba.Mba | NJ mmepụta oyiri |
IGFBP-1 | AB0028-1 | 4H6-2 |
AB0028-2 | 4C2-3 | |
AB0028-3 | 2H11-1 | |
AB0028-4 | 3G12-11 |
Mara: Bioantibody nwere ike ahaziri nha maka mkpa gị.
1.Rutanen EM .Ihe uto nke insulin na-ejikọta protein 1: US 1996.
2.Harman, S, Mitchell, et al.Ọbara Ọbara nke Insulin-dị ka Uto Factor I (IGF-I), IGF-II, IGF-Binding Protein-3, na Prostate-Specific Antigen dị ka amụma nke Clinical Prostate Cancer[J].Akwụkwọ akụkọ nke Clinical Endocrinology & Metabolism, 2000.