MMP-3 mgbochi mmadụ, Mouse Monoclonal
Nkọwa ngwaahịa
Ozi izugbe
Matrix metallopeptidase 3 (nke a na-akpọ MMP3) bụ nke a makwaara dị ka stromelysin 1 na progelatinase.MMP3 bụ otu ezinụlọ matrix metalloproteinase (MMP) nke ndị otu ya na-etinye aka na nbibi nke matrix extracellular na usoro physiological nkịtị, dị ka mmepe embrayo, mmeputakwa, nhazigharị anụ ahụ, na usoro ọrịa gụnyere ogbu na nkwonkwo na metastasis.Dịka endopeptidase nke dabere na zinc zoro ezo, MMP3 na-arụ ọrụ ya tumadi na matriks extracellular.Ndị inhibitors abụọ bụ isi na-arụ ọrụ protein a: alfa2-macroglobulin na anụ ahụ inhibitors nke metalloproteases (TIMPs).MMP3 na-arụ ọrụ dị mkpa n'ịkwada ụdị collagen II, III, IV, IX, na X, proteoglycans, fibronectin, laminin, na elastin.Ọzọkwa, MMP3 nwere ike ịrụ ọrụ MMP ndị ọzọ dị ka MMP1, MMP7, na MMP9, na-eme ka MMP3 dị oke mkpa na nhazigharị anụ ahụ njikọ.Ngwọta nke MMP abanyela n'ọtụtụ ọrịa gụnyere ọrịa ogbu na nkwonkwo, ọnya na-adịghị ala ala, encephalomyelitis, na kansa.Ihe mgbochi synthetic ma ọ bụ eke sitere n'okike nke MMP na-ebute mgbochi nke metastasis, ebe nhazi nke MMP mere ka mbuso agha sel cancer dịkwuo elu.
Njirimara
| Nkwanye ụzọ abụọ | CLIA (Nchọpụta-Nchọpụta): 11G11-6 ~ 8A3-9 11G11-6 ~ 5B9-4 |
| Ịdị ọcha | > 95%, nke SDS-PAGE kpebiri |
| Nhazi ihe nchekwa | PBS, pH7.4. |
| Nchekwa | Chekwaa ya n'okpuru ọnọdụ adịghị mma na -20 ℃ ruo -80 ℃ mgbe ị na-enweta ya. Na-akwado iwebata protein n'ime obere nha maka nchekwa kacha mma. |
Ntụnyere asọmpi
Ozi ịtụ
| Aha ngwaahịa | Nwamba.Mba | NJ mmepụta oyiri |
| MMP-3 | AB0025-1 | 11G11-6 |
| AB0025-2 | 8A3-9 | |
| AB0025-3 | 5B9-4 |
Mara: Bioantibody nwere ike ahaziri nha maka mkpa gị.
Nkọwapụta
1.Yamanaka H , Matsuda Y , Tanaka M , et al.Serum matrix metalloproteinase 3 dị ka onye amụma nke ogo mbibi nkwonkwo n'ime ọnwa isii ka emechara, na ndị ọrịa nwere ọrịa ogbu na nkwonkwo n'oge [J].Arthrits & Rheumatism, 2000, 43 (4): 852–858.
2.Hattori Y , Kida D , Kaneko A .Enwere ike iji ọkwa serum matrix metalloproteinase-3 mee ihe iji buru amụma mgbaghara ụlọ ọgwụ na ọrụ anụ ahụ nkịtị na ndị ọrịa nwere ọrịa ogbu na nkwonkwo [J].Clinical Rheumatology, 2018.
