Ozi izugbe
Pepsinogen I, ndị na-ebute pepsin, bụ mucosa gastric na-emepụta ma wepụta ya n'ime lumen gastric na mgbasa ozi dị n'akụkụ.Pepsinogen nwere otu yini polypeptide nke amino acid 375 nwere nkezi ịdị arọ molekụla nke 42 kD.A na-ezobe PG I (isoenzyme 1-5) tumadi site na sel ndị isi na mucosa fundic, ebe PG II (isoenzyme 6-7) na-ezobe ya site na gland pyloric na mucosa duodenal proximal.
Precursor na-egosipụta ọnụọgụ nke mkpụrụ ndụ elu afọ yana sel glandular, ma na-enyocha atrophy gastric na-apụtaghị ìhè.Ha kwụsiri ike nke ukwuu n'ihi na ha na-arụ ọrụ ha n'okpuru ọnọdụ ọjọọ dị na sistem nri nri.Atrophy nke mucosa corpus na-eduga na njikọ dị ala nke pepsinogen I na ya mere ntọhapụ ya dị ala na serum.Serum pepsinogen I na-egosi ọrụ na steeti mucosa afọ.
Nkwanye ụzọ abụọ | CLIA (Nchọpụta-Nchọpụta): 1C1-3 ~ 1G7-3 1E3-1 ~ 1G7-3 |
Ịdị ọcha | > 95%, nke SDS-PAGE kpebiri |
Nhazi ihe nchekwa | 20mM PB, 150mM NaCl, 0.1% Proclin 300, pH7.4 |
Nchekwa | Chekwaa ya n'okpuru ọnọdụ adịghị mma na -20 ℃ ruo -80 ℃ mgbe ị na-enweta ya. Na-akwado iwebata protein n'ime obere nha maka nchekwa kacha mma. |
Aha ngwaahịa | Nwamba.Mba | NJ mmepụta oyiri |
PGI | AB0005-1 | 1C1-3 |
AB0005-2 | 1E3-1 | |
AB0005-3 | 1G7-3 |
Mara: Bioantibody nwere ike ahaziri nha maka mkpa gị.
1.Sipponen P, Ranta P, Helske T, et al.Ọbara ọbara nke gastrin-17 na pepsinogen I na atrophic gastritis: ihe ọmụmụ ihe na-ahụ maka nchịkwa.[J].Akwụkwọ akụkọ Scandinavian nke Gastroenterology, 2002, 37 (7): 785-791.
2.Mangla JC , Schenk EA , Desbaillets L , et al.Pepsin secretion, pepsinogen, na gastrin na Barrett's esophagus'.Njirimara ụlọ ọgwụ na morphological[J].Gastroenterology, 1976, 70 (5 PT.1): 669-676.