Helicobacter pylori (HP) bụ nje bacteria na-ebi n'ime afọ ma na-arapara n'ahụ mucosa gastric na oghere intercellular, na-ebute mbufụt.Ọrịa HP bụ otu n'ime nje na-efe efe na-efe efe, na-ebute ọtụtụ ijeri mmadụ n'ụwa niile.Ha bụ ihe kacha akpata ọnya na gastritis (mbufụt nke eriri afọ).

Ọrịa dị elu na ụmụaka na nchịkọta ezinụlọ bụ njirimara dị ịrịba ama nke ọrịa HP, na nnyefe ezinụlọ nwere ike ịbụ isi ụzọ ọrịa HP bụ isi ihe na-akpata ọrịa gastritis na-adịghị ala ala, ọnya peptic, gastric mucosa-Associated lymphoid tissue (MALT) lymphoma, na ọrịa kansa afọ.Na 1994, Òtù Ahụ Ike Ụwa/International Agency for Research on Cancer (WHO/IARC) họpụtara Helicobacter pylori dị ka klas I carcinogen.

Mucosa gastric - ihe agha nke afọ

N'okpuru ọnọdụ nkịtị, mgbidi afọ nwere usoro nchebe onwe ya zuru oke (ihe nzuzo nke gastric acid na protease, nchebe nke mmiri na-adịghị ike na nke soluble, mgbatị ahụ mgbe niile, wdg), nke nwere ike iguzogide mbuso agha nke ọtụtụ puku microorganisms. nke na-esi n'ọnụ abanye.

HP nwere flagella nọọrọ onwe ya na usoro helical pụrụ iche, nke na-abụghị naanị na-arụ ọrụ mgbakasị ahụ n'oge ọchịchị nje, kamakwa ọ nwere ike bụrụ okirikiri ma mepụta morphology na-echebe onwe ya na gburugburu ebe ọjọọ.N'otu oge ahụ, Helicobacter pylori nwere ike ịmepụta nsị dị iche iche, nke na-achọpụta na Helicobacter pylori nwere ike ịgafe oyi akwa gastric site n'ike nke aka ya ma guzogide acid gastric na ihe ndị ọzọ na-adịghị mma, na-aghọ nanị microorganism nke nwere ike ịdị ndụ na afọ mmadụ. .

Pathogenesis nke Helicobacter pylori

1. Dị ike

Nnyocha e mere egosiwo na Helicobacter pylori nwere ikike siri ike ịkwaga na gburugburu ebe viscous, na flagella dị mkpa maka nje bacteria na-egwu mmiri na oyi akwa mkpuchi nke dị n'elu mucosa gastric.

2. Protein metụtara Endotoxin A (CagA) na vacuolar toxin (VacA)

Cytotoxin-metụtara mkpụrụ ndụ ihe nketa A (CagA) nke HP zoro ezo nwere ike ịkpalite mmeghachi omume mkpasu iwe mpaghara.Ọrịa Helicobacter pylori dị mma nke CagA nwekwara ike ịbawanye ohere nke gastritis atrophic, metaplasia eriri afọ na ọrịa kansa afọ.

Ịkwụsị cytotoxin A (VacA) bụ ihe ọzọ na-akpata ọrịa Helicobacter pylori, nke nwere ike ịbanye mitochondria iji mezie ọrụ nke akụkụ ahụ.

3. Flagellin

Protein flagellin abụọ, FlaA na FlaB, mebere isi ihe dị na filament flagellar.Mgbanwe na flagellin glycosylation na-emetụta motility nje.Mgbe ọkwa nke glycosylation protein FlaA mụbara, ma ikike ịkwaga na ibu nchịkwa nke ụdị ahụ mụbara.

4. Uwease

Urease na-emepụta NH3 na CO2 site na hydrolyzing urea, nke na-ewepụ acid gastric ma na-ebuli pH nke sel ndị gbara ya gburugburu.Na mgbakwunye, urease na-ekere òkè na nzaghachi mkpali ma na-akwalite adhesion site na mmekọrịta ya na ndị na-anabata CD74 na cell epithelial gastric.

5. Protein ujo ọkụ HSP60/GroEL

Helicobacter pylori na-amịkọrọ ọtụtụ protein ndị na-atụ egwu okpomọkụ echekwara nke ọma, nke njikọta nke Hsp60 na urease na E. coli na-abawanye ọrụ urease nke ukwuu, na-ekwe ka nje ahụ gbanwee wee dịrị ndụ na niche gburugburu ebe obibi nke afọ mmadụ.

6. Protein metụtara nko 2 homolog FliD

FliD bụ protein arụpụtara nke na-echebe ọnụ flagella ma nwee ike itinye flagellin ugboro ugboro ka ọ too filamenti flagellar.A na-ejikwa FliD dị ka molekul adhesion, na-amata mkpụrụ ndụ glycosaminoglycan nke sel ndị ọbịa.N'ime ndị ọbịa butere ọrịa ahụ, ọgwụ mgbochi flid bụ akara nke ọrịa na enwere ike iji ya mee nchọpụta serological.

Ụzọ nnwale:

1. Nnwale stool: Nnwale stool antigen bụ ule na-adịghị emerụ ahụ maka H. pylori.Ọrụ dị mma, dị mfe na ngwa ngwa, na ọ dịghị achọ ọnụ nchịkwa nke ọ bụla reagents.

2. Serum antibody detection: Mgbe ọrịa Helicobacter pylori pụtara n'ime ahụ, ahụ mmadụ ga-enwe ọgwụ mgbochi Helicobacter pylori n'ime ọbara n'ihi nzaghachi mgbochi.Site n'iwere ọbara iji lelee mkpokọta ọgwụ mgbochi Helicobacter pylori, ọ nwere ike igosipụta ma enwere Helicobacter pylori n'ime ahụ.nje nje.

3. Nnwale iku ume: Nke a bụ usoro nyocha kachasị ewu ewu ugbu a.Urea ọnụ nwere 13C ma ọ bụ 14C, na ume na-anwale mkpokọta carbon dioxide nwere 13C ma ọ bụ 14C ka oge na-aga, n'ihi na ọ bụrụ na enwere Helicobacter pylori, urea ga-achọpụta ya site na urea akọwapụtara.Enzymes ndị ahụ na-akụda n'ime amonia na carbon dioxide, nke a na-esi na ngụgụ na-esi n'ọbara na-ekupụ.

4. Endoscopy: na-enye ohere iji nlezianya nyochaa njirimara mucosal gastric dị ka ọbara ọbara, ọzịza, mgbanwe nodular, wdg;endoscopy adịghị mma maka ndị ọrịa nwere nsogbu siri ike ma ọ bụ contraindications na ụgwọ ndị ọzọ (nkụnwụ, ike)).

Ngwaahịa metụtara bioantibody nke H.pylorindụmọdụ:

Ngwa nyocha ngwa ngwa H. Pylori Antigen (Chromatography Lateral)

Ngwa nyocha ngwa ngwa H. Pylori Antibody (Chromatography Lateral)